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Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections (Boolell et al 1996). It soon became a extreme success: annual sales of Viagra in the period 1999-2001 exceeded $1 billion. Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. It was initially studied for apply in hypertension (high blood pressure) and angina pectoris (a shape of cardiovascular disease). Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent research facility. The medication was patented in 1996, approved for consume in erectile dysfunction by the FDA on March 27, 1998, becoming the first medication approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year (Kling 1998).
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